Riluzole increases high-affinity glutamate uptake in rat spinal cord synaptosomes

  title={Riluzole increases high-affinity glutamate uptake in rat spinal cord synaptosomes},
  author={R. D. Azbill and X. Mu and J. Springer},
  journal={Brain Research},
  • R. D. Azbill, X. Mu, J. Springer
  • Published 2000
  • Chemistry, Medicine
  • Brain Research
  • The purpose of this study was to examine the effect of the anti-convulsant agent, riluzole, on high-affinity glutamate uptake as measured in rat spinal cord synaptosomes. The rate of glutamate uptake was significantly increased in the presence of 0.1 microM and 1.0 microM riluzole, but not at the higher concentrations examined. Kinetics analysis demonstrated that riluzole (0.1 microM) decreased the apparent K(m) by 21% and increased the V(max) by 31%. Glutamate uptake also was significantly… CONTINUE READING
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