Riluzole in psychiatry: a systematic review of the literature.

  title={Riluzole in psychiatry: a systematic review of the literature.},
  author={Carlos A. Zarate and Husseini K. Manji},
  journal={Expert opinion on drug metabolism & toxicology},
  volume={4 9},
BACKGROUND The glutamate system seems to be an important contributor to the pathophysiology of mood and anxiety disorders. Thus, glutamatergic modulators are reasonable candidate drugs to test in patients with mood and anxiety disorders. Riluzole, a neuroprotective agent with anticonvulsant properties approved for the treatment of amyotrophic lateral sclerosis (ALS) is one such agent. OBJECTIVE To assess the potential risks and benefits of riluzole treatment in psychiatric patients. METHODS… CONTINUE READING