Riluzole attenuates excitatory amino acid transporter type 3 activity in Xenopus oocytes via protein kinase C inhibition.

@article{Choi2013RiluzoleAE,
  title={Riluzole attenuates excitatory amino acid transporter type 3 activity in Xenopus oocytes via protein kinase C inhibition.},
  author={Jung-Seok Choi and Jung-Hee Ryu and Zhiyi Zuo and S Yang and Hye-Won Chang and S G Do},
  journal={European journal of pharmacology},
  year={2013},
  volume={713 1-3},
  pages={39-43}
}
This study aimed to evaluate the effect of riluzole on the activity of excitatory amino acid transporter type 3 (EAAT3), a neuronal glutamate transporter, and to investigate the role of protein kinase C (PKC) in this effect. EAAT3 expression was induced in Xenopus oocytes by injecting EAAT3 mRNA. Using the two-electrode voltage clamping method, membrane currents were recorded before, during, and after applying l-glutamate (30 μM) in the absence and presence of prior incubation with riluzole (0… CONTINUE READING