Riluzole, a glutamate release inhibitor, and motor behavior

  title={Riluzole, a glutamate release inhibitor, and motor behavior},
  author={B. Kretschmer and U. Kratzer and W. J. Schmidt},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  • B. Kretschmer, U. Kratzer, W. J. Schmidt
  • Published 1998
  • Medicine, Chemistry
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • Riluzole (2-amino-6-trigluoromethoxy benzothiazole) has neuroprotective, anticonvulsant, anxiolytic and anesthetic qualities. These effects are mediated by blockade of glutamate transmission, stabilizing of sodium channels and blockade of γ-aminobutyric acid (GABA) reuptake. The action profile of riluzole is dominated by its effects on glutamate transmission which are predominately mediated by N-methyl-D-aspartate (NMDA) receptor-linked processes in vitro. In vivo studies show that blockade and… CONTINUE READING
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