Rikkunshi-to raises levels of somatostatin and gastrin in human plasma.

  title={Rikkunshi-to raises levels of somatostatin and gastrin in human plasma.},
  author={Takafumi Naito and Hiroki Itoh and Fumitaka Yasunaga and Masaharu Takeyama},
  journal={Biological & pharmaceutical bulletin},
  volume={24 7},
Rikkunshi-to, a traditional Chinese (Kampo) medicine, has been used to treat chronic hypofunctions of the gastrointestinal tract. The effects of Rikkunshi-to on the plasma levels of gut-regulated peptide (somatostatin, motilin, gastrin, and vasoactive intestinal peptide (VIP)) levels were studied in healthy subjects. A single oral administration of Rikkunshi-to caused significant increases in plasma somatostatin and gastrin levels at 60 to 240 min compared with a placebo group. On the other… CONTINUE READING

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