Rigidity sensing and adaptation through regulation of integrin types


Tissue rigidity regulates processes in development, cancer and wound healing. However, how cells detect rigidity, and thereby modulate their behaviour, remains unknown. Here, we show that sensing and adaptation to matrix rigidity in breast myoepithelial cells is determined by the bond dynamics of different integrin types. Cell binding to fibronectin through… (More)
DOI: 10.1038/nmat3960


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@inproceedings{ElseguiArtola2014RigiditySA, title={Rigidity sensing and adaptation through regulation of integrin types}, author={Alberto El{\'o}segui-Artola and Elsa Bazelli{\`e}res and Michael D Allen and Ion Andreu and Roger Oria and Raimon Sunyer and Jennifer J. Gomm and John F Marshall and Janet Jones and Xavier Trepat and Pere Roca-Cusachs}, booktitle={Nature materials}, year={2014} }