Rigid firing sequences undermine spatial memory codes in a neurodegenerative mouse model

@inproceedings{Cheng2013RigidFS,
  title={Rigid firing sequences undermine spatial memory codes in a neurodegenerative mouse model},
  author={Jingheng Cheng and Daoyun Ji},
  booktitle={eLife},
  year={2013}
}
Hippocampal neurons encode spatial memories by firing at specific locations. As the animal traverses a spatial trajectory, individual locations along the trajectory activate these neurons in a unique firing sequence, which yields a memory code representing the trajectory. How this type of memory code is altered in dementia-producing neurodegenerative disorders is unknown. Here we show that in transgenic rTg4510 mice, a model of tauopathies including Alzheimer's disease, hippocampal neurons did… CONTINUE READING
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