Right ventricular beneficial effects of beta adrenergic receptor kinase inhibitor (betaARKct) gene transfer in a rat model of severe pressure overload.

@article{Molina2009RightVB,
  title={Right ventricular beneficial effects of beta adrenergic receptor kinase inhibitor (betaARKct) gene transfer in a rat model of severe pressure overload.},
  author={Ezequiel J. Molina and Dipin Gupta and Jon Palma and John P. Gaughan and Mahender Macha},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2009},
  volume={63 5},
  pages={331-6}
}
Heart failure is associated with abnormalities in betaAR cascade regulation, calcium cycling, expression of inflammatory mediators and apoptosis. Adenoviral mediated gene transfer of betaARKct has beneficial indirect effects on these pathologic processes upon the left ventricular myocardium. The concomitant biochemical changes that occur in the right ventricle have not been well characterized. Sprague-Dawley rats underwent aortic banding and were followed by echocardiography. After a decrease… CONTINUE READING