Right place, right time, right peptide: DO keeps DM focused.

  title={Right place, right time, right peptide: DO keeps DM focused.},
  author={Lisa K. Denzin and Jennifer L. Fallas and Maria J Prendes and Woelsung Yi},
  journal={Immunological reviews},
Peptide loading of major histocompatibility class II molecules is catalyzed in late endosomal and lysosomal compartments of cells by the catalytic action of human leukocyte antigen (HLA)-DM (H-2M in mice). In B cells, dendritic cells and thymic epithelial cells, the peptide loading of class II molecules is modified by the expression of the non-classical class II molecule, HLA-DO (H-2O in mice). Collectively, studies to date support that DO/H-2O expression inhibits the presentation of antigens… CONTINUE READING

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