Right on target: eradicating leukemic stem cells.

  title={Right on target: eradicating leukemic stem cells.},
  author={Daniela S Krause and Richard A. Van Etten},
  journal={Trends in molecular medicine},
  volume={13 11},
Less than a third of adults with acute myeloid leukemia (AML) are cured by current treatments, emphasizing the need for new approaches to therapy. The discovery over a decade ago that myeloid leukemias originate from rare stem-like cells that can transfer the disease to immunodeficient mice suggested that these 'leukemia stem cells' (LSCs) are responsible for relapse of leukemia following conventional or targeted cancer therapy and that eradication of LSCs might be necessary to cure the disease… CONTINUE READING


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Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia

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  • Cancer Cell
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