Rifaximin for the treatment of diarrhoea-predominant irritable bowel syndrome

@article{Laterza2015RifaximinFT,
  title={Rifaximin for the treatment of diarrhoea-predominant irritable bowel syndrome},
  author={Lucrezia Laterza and Gianluca Ianiro and Iolanda Scoleri and Rosario Landi and Giovanni Bruno and Franco Scaldaferri and Eleonora Gaetani and Mariachiara Campanale and Antonio Gasbarrini},
  journal={Expert Opinion on Pharmacotherapy},
  year={2015},
  volume={16},
  pages={607 - 615}
}
Introduction: Rifaximin is a non-absorbable, semisynthetic antibiotic that acts as an inhibitor of bacterial RNA synthesis, with a broad spectrum of antibacterial activity. Due to its poor absorption, rifaximin has an increased exposure to the intestine, thus it is suitable for the treatment of many gastrointestinal (GI) diseases. In irritable bowel syndrome (IBS) pathogenesis, gut microbiota impairment may play a major role. The possibility of modulating intestinal bacteria using antibiotics… 
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TLDR
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