Rifaximin for the treatment of irritable bowel syndrome – a drug safety evaluation

@article{Ponziani2016RifaximinFT,
  title={Rifaximin for the treatment of irritable bowel syndrome – a drug safety evaluation},
  author={Francesca Romana Ponziani and Silvia Pecere and Loris Riccardo Lopetuso and Franco Scaldaferri and Giovanni Cammarota and Antonio Gasbarrini},
  journal={Expert Opinion on Drug Safety},
  year={2016},
  volume={15},
  pages={983 - 991}
}
ABSTRACT Introduction: Irritable bowel syndrome is a functional gastrointestinal disorder with a multifactorial etiology. Alterations of intestinal motility and immunity, gut-brain interactions, as well as gut microbiota dysbiosis contribute to the development of irritable bowel syndrome. Therefore, gut microbiota modulation by non-absorbable antibiotics is a therapeutic option in patients with IBS. Areas covered: Published articles including patients with irritable bowel syndrome reporting… 
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Rifaximin Re-treatment in Patients with Irritable Bowel Syndrome: Feels Like the First Time?
TLDR
The TARGET-3 has demonstrated that re-treatment is effective in IBS patients who initially respond to rifaximin and experience relapsing symptoms, which is a crucial issue when an antibiotic is used in clinical practice, as the development of mechanisms of resistance among bacteria may affect clinical efficacy.
Current and emerging pharmacological approaches for treating diarrhea-predominant irritable bowel syndrome
TLDR
Clinical trial data applicable to the current FDA approved IBS-D therapies as well as review data related to new and emerging therapies for this condition are discussed.
Dietary geraniol ameliorates intestinal dysbiosis and relieves symptoms in irritable bowel syndrome patients: a pilot study
TLDR
The results show that orally administered Ge-OH is a powerful modulator of the intestinal microbial ecosystem, capable of leading to increased relative abundances of Collinsella and especially Faecalibacterium, a well-known health-promoting butyrate producer consistently found to be decreased in IBS patients.
Eubiotic properties of rifaximin: Disruption of the traditional concepts in gut microbiota modulation
TLDR
An increase in Bifidobacterium, Faecalibacterium prausnitzii and Lactobacillus abundance after rifaximin treatment is demonstrated, probably consequent to the induction of bacterial resistance, with no major change in the overall gut microbiota composition.
New concepts on intestinal microbiota and the role of the non-absorbable antibiotics with special reference to rifaximin in digestive diseases.
Diagnosis and treatment of gastrointestinal dysfunction in hereditary TTR amyloidosis
TLDR
Gastroenterologists play a valuable role in both the diagnosis and the timely management of gastrointestinal symptoms in hereditary transthyretin amyloidosis and should, therefore, be part of a multidisciplinary and comprehensive approach to this disorder.
Colonic diverticular disease
TLDR
The epidemiology, pathophysiology, diagnosis and management of diverticular disease, characterized by sac-like protrusions on the wall of the large intestine, is one of the most common conditions detected on colonoscopy in the adult population.
Antibiotic Use and Microbiota
TLDR
A review of antibiotics or antibiotic combinations in relation to changes in the microbiota composition and their molecular agents (genes, proteins, and metabolites), primarily the bowel is presented.
Therapeutische Modulation der Darmmikrobiota beim Reizdarmsyndrom
TLDR
An overview of four current options for the treatment of irritable bowel syndrome, which are characterized by modulation of intestinal microbiota, is given and the antibiotic rifaximin is effective in selected patients.
Antibiotic use and microbiome function
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References

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