Rifaximin alters intestinal bacteria and prevents stress-induced gut inflammation and visceral hyperalgesia in rats.

@article{Xu2014RifaximinAI,
  title={Rifaximin alters intestinal bacteria and prevents stress-induced gut inflammation and visceral hyperalgesia in rats.},
  author={Dabo Xu and Jun Gao and Merritt G Gillilland and Xiaoyin Wu and Il Han Song and John Y Kao and Chung Owyang},
  journal={Gastroenterology},
  year={2014},
  volume={146 2},
  pages={484-96.e4}
}
BACKGROUND & AIMS Rifaximin is used to treat patients with functional gastrointestinal disorders, but little is known about its therapeutic mechanism. We propose that rifaximin modulates the ileal bacterial community, reduces subclinical inflammation of the intestinal mucosa, and improves gut barrier function to reduce visceral hypersensitivity. METHODS We induced visceral hyperalgesia in rats, via chronic water avoidance or repeat restraint stressors, and investigated whether rifaximin… CONTINUE READING

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