Rifamycins Inhibit Human Neutrophil Functions: New Derivatives with Potential Antiinflammatory Activity

Abstract

In our study we investigated the effect of rifamycin SV, rifamycin B, rifampicin and five semisynthetic derivatives on human neutrophil functions such as locomotion, superoxide production and degranulation stimulated by specific agonists. All compounds were tested at concentrations ranging from 10−9 to 10−5 M. Among the newly synthesized compounds the most… (More)
DOI: 10.1023/A:1027314419843

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