Rifampin-resistant RNA polymerase mutants of Chlamydia trachomatis remain susceptible to the ansamycin rifalazil.

@article{Suchland2005RifampinresistantRP,
  title={Rifampin-resistant RNA polymerase mutants of Chlamydia trachomatis remain susceptible to the ansamycin rifalazil.},
  author={Robert J. Suchland and Agn{\`e}s Bourillon and Erick Denamur and William E. Stamm and David Michael Rothstein},
  journal={Antimicrobial agents and chemotherapy},
  year={2005},
  volume={49 3},
  pages={
          1120-6
        }
}
Stable, homotypic mutants of Chlamydia trachomatis for which MICs of rifampin and rifalazil are elevated were isolated by serial passage at sub-MIC concentrations of these compounds. An alternative approach, in which Chlamydia cells were incubated and subsequently passaged three times, all in the presence of the selective agent at concentrations above the MIC, appeared to be a more effective means of selecting for mutants. In every instance where an elevation in the MIC occurred, one or more… CONTINUE READING

Figures, Tables, and Topics from this paper.

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 19 CITATIONS

Activities of rifamycin derivatives against wild-type and rpoB mutants of Chlamydia trachomatis.

  • Antimicrobial agents and chemotherapy
  • 2005
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Genomic Stability of Genotyping Markers in Chlamydia trachomatis

  • Front. Cell. Inf. Microbio.
  • 2012
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 19 REFERENCES

Assessment of antimicrobial resistance in Chlamydia trachomatis strains associated with treatment failure or same strain recurrence, p. 353–360

W. E. Stamm, W. M. Geisler, R. J. Suchland
  • Basim Yeri: GRAFMAT Basim ve Reklam Sanayi Tic. Ltd. Sti.,
  • 2002
VIEW 2 EXCERPTS

Cross-resistance between rifampicin and KRM-1648 is associated with specific rpoB alleles in Mycobacterium tuberculosis.

  • The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
  • 2002
VIEW 2 EXCERPTS

Differential effect of rpoB mutations on antibacterial activities of rifampicin and KRM-1648 against Staphylococcus aureus

T. A. Wichelhaus, V. Schafer, V. Brade, B. Boddinghaus
  • J. Antimicrob. Chemother
  • 2001
VIEW 3 EXCERPTS