Rifampin resistance in Neisseria meningitidis due to alterations in membrane permeability.

@article{Abadi1996RifampinRI,
  title={Rifampin resistance in Neisseria meningitidis due to alterations in membrane permeability.},
  author={Fariborz J.R. Abadi and Philip E. Carter and Phil Cash and Thomas Hugh Pennington},
  journal={Antimicrobial agents and chemotherapy},
  year={1996},
  volume={40 3},
  pages={
          646-51
        }
}
Rifampin-resistant (Rifr) Neisseria meningitidis strains are known to have single point mutations in the central conserved regions of the rpoB gene. We have demonstrated two distinct resistance phenotypes in strains with identical mutations in this region, an intermediate level of resistance in Rifr clinical isolates and a high level of resistance in mutants selected in vitro. The possible role of membrane permeability in the latter was investigated by measuring MICs in the presence of Tween 80… CONTINUE READING

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