Rifampin modulation of xeno‐ and endobiotic conjugating enzyme mRNA expression and associated microRNAs in human hepatocytes

@inproceedings{Gufford2018RifampinMO,
  title={Rifampin modulation of xeno‐ and endobiotic conjugating enzyme mRNA expression and associated microRNAs in human hepatocytes},
  author={Brandon T Gufford and Jason Robarge and Michael T Eadon and Hongyu Gao and Hai Lin and Yunlong Liu and Zeruesenay Desta and Todd C. Skaar},
  booktitle={Pharmacology research & perspectives},
  year={2018}
}
Rifampin is a pleiotropic inducer of multiple drug metabolizing enzymes and transporters. This work utilized a global approach to evaluate rifampin effects on conjugating enzyme gene expression with relevance to human xeno- and endo-biotic metabolism. Primary human hepatocytes from 7 subjects were treated with rifampin (10 μmol/L, 24 hours). Standard… CONTINUE READING