Rifampin markedly decreases plasma concentrations of praziquantel in healthy volunteers.

@article{Ridtitid2002RifampinMD,
  title={Rifampin markedly decreases plasma concentrations of praziquantel in healthy volunteers.},
  author={Wibool Ridtitid and Malinee Wongnawa and Werawath Mahatthanatrakul and Jarurat Punyo and Methi Sunbhanich},
  journal={Clinical pharmacology and therapeutics},
  year={2002},
  volume={72 5},
  pages={505-13}
}
BACKGROUND AND OBJECTIVE Praziquantel is extensively metabolized by the hepatic cytochrome P450 (CYP) enzymes. The CYP3A isoforms are likely to be major enzymes responsible for praziquantel metabolism. Rifampin (INN, rifampicin), a potent enzyme inducer of CYP-mediated metabolism (especially CYP2C9, CYP2C19, and CYP3A4), is known to markedly decrease plasma concentrations and effects of a number coadministered drugs. The aim of this investigation was to study the possible pharmacokinetic… CONTINUE READING