Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolites

@article{Backman2005RifampinMD,
  title={Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolites},
  author={Janne T. Backman and Harri Luurila and Mikko Neuvonen and Pertti J. Neuvonen},
  journal={Clinical Pharmacology \& Therapeutics},
  year={2005},
  volume={78}
}
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To assess the effects of the cytochrome P450 (CYP) 3A genotype, CYP3A5, on atorvastatin pharmacokinetics and its interaction with clarithromycin.
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TLDR
The effects of cyclosporine and gemfibrozil explain the increased plasma statin concentrations and, together with pharmacodynamic factors, the increased risk of myotoxicity when coadministered with statins.
Gemfibrozil in Combination with Statins—Is It Really Contraindicated?
TLDR
Understanding the metabolism of gemfibrozil and the degree of interaction with the various statins will assist health-care providers to optimize safety when this combination is clinically indicated.
Drug–drug interactions that interfere with statin metabolism
TLDR
The pharmacokinetic aspects of the drug–drug interaction with statins and genetic polymorphisms in CYPs, which are involved in the metabolism of statins, are discussed and the importance of establishing a system utilizing electronic medical information practically to avoid adverse drug reactions is highlighted.
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References

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Plasma concentrations of active lovastatin acid are markedly increased by gemfibrozil but not by bezafibrate
TLDR
The effects of bezafibrate and gemfibrozil on the pharmacokinetics of lovastatin were studied to study the effects of fibrates with statins and the underlying mechanism of this adverse reaction remains unclear.
Rifampin greatly reduces plasma simvastatin and simvastatin acid concentrations
TLDR
Rifampin (rifampicin) is a potent inducer of several cytochrome P450 (CYP) enzymes, including CYP3A4, and its effect on the pharmacokinetics of simvastatin is investigated.
Plasma concentrations of active simvastatin acid are increased by gemfibrozil
TLDR
The aim of this study was to determine whether gemfibrozil affects the pharmacokinetics of simvastatin and whether it affects CYP3A4 activity in vitro.
Gemfibrozil greatly increases plasma concentrations of cerivastatin
TLDR
The effect of gemfibrozil on cerivastatin pharmacokinetics was studied to study the mechanism of this potentially fatal drug interaction.
Effect of itraconazole on the pharmacokinetics of atorvastatin
The effect of gemfibrozil on the pharmacokinetics of rosuvastatin
Efficacy of statin therapy: possible effect of phenytoin
TLDR
A patient with familial hypercholesterolaemia and epilepsy in whom the introduction and subsequent discontinuation of phenytoin were associated with marked changes in the lipid response to treatment with simvastatin and atorvastasin is reported.
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