Rifampin induces hydroxyl radical formation in Mycobacterium tuberculosis.

@article{Piccaro2014RifampinIH,
  title={Rifampin induces hydroxyl radical formation in Mycobacterium tuberculosis.},
  author={Giovanni Piccaro and Donatella Pietraforte and Federico Giannoni and Alessandro Mustazzolu and Lanfranco 7 Fattorini},
  journal={Antimicrobial agents and chemotherapy},
  year={2014},
  volume={58 12},
  pages={
          7527-33
        }
}
The antituberculosis (anti-TB) drug rifampin (RIF) binds to the beta subunit of the RNA polymerase (RpoB) of Mycobacterium tuberculosis, but the bactericidal responses triggered after target interaction are not known. To evaluate whether RIF induced an oxidative burst, lysates of RIF-treated M. tuberculosis were tested for determination of reactive oxygen species (ROS) by the electron paramagnetic resonance (EPR) technique using 1-hydroxy-3-carboxy-pyrrolidine (CPH) and 5,5-dimethyl-1… CONTINUE READING
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