Rifampicin resistance in Neisseria meningitidis: evidence from a study of sibling strains, description of new mutations and notes on population genetics.

@article{Nolte1997RifampicinRI,
  title={Rifampicin resistance in Neisseria meningitidis: evidence from a study of sibling strains, description of new mutations and notes on population genetics.},
  author={Oliver Nolte},
  journal={The Journal of antimicrobial chemotherapy},
  year={1997},
  volume={39 6},
  pages={747-55}
}
  • Oliver Nolte
  • Published 1997 in The Journal of antimicrobial chemotherapy
To provide direct evidence for the mechanism leading to resistance to rifampicin, two Neisseria meningitidis strains from one clonal lineage (so-called sibling strains) were studied; one of these strains was resistant, the other sensitive to rifampicin. The polymerase chain reaction (PCR) was used to amplify fragments of the known rifampicin resistance region on the rpoB gene coding for the beta subunit of DNA-directed RNA polymerase and the amplimers were then sequenced. In addition to the DNA… CONTINUE READING

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