Rifampicin has a profound effect on the pharmacokinetics of oral S-ketamine and less on intravenous S-ketamine.

@article{Peltoniemi2012RifampicinHA,
  title={Rifampicin has a profound effect on the pharmacokinetics of oral S-ketamine and less on intravenous S-ketamine.},
  author={Marko A. Peltoniemi and Teijo I Saari and Nora M. Hagelberg and Kari Laine and Kaisa J Kurkinen and Pertti J Neuvonen and Klaus T. Olkkola},
  journal={Basic & clinical pharmacology & toxicology},
  year={2012},
  volume={111 5},
  pages={325-32}
}
Low-dose ketamine is currently used in several acute and chronic pain conditions as an analgesic. Ketamine undergoes extensive metabolism and is thus susceptible to drug-drug interactions. We examined the effect rifampicin, a well-known inducer of many cytochrome P450 (CYP) enzymes and transporters, on the pharmacokinetics of intravenous and oral S-ketamine in healthy volunteers. Eleven healthy volunteers were administered in randomized order 600 mg rifampicin or placebo orally for 6 days in a… CONTINUE READING

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