Rifampicin fails to eradicate mature biofilm formed by methicillin-resistant Staphylococcus aureus.

@article{Reiter2012RifampicinFT,
  title={Rifampicin fails to eradicate mature biofilm formed by methicillin-resistant Staphylococcus aureus.},
  author={Keli Cristine Reiter and Gustavo Enck Sambrano and B{\'a}rbara Villa and Thiago Galv{\~a}o da Silva Paim and Caio Fernando Ramalho de Oliveira and Pedro Alves D'azevedo},
  journal={Revista da Sociedade Brasileira de Medicina Tropical},
  year={2012},
  volume={45 4},
  pages={471-4}
}
INTRODUCTION Antimicrobial activity on biofilms depends on their molecular size, positive charges, permeability coefficient, and bactericidal activity. Vancomycin is the primary choice for methicillin-resistant Staphylococcus aureus (MRSA) infection treatment; rifampicin has interesting antibiofilm properties, but its effectivity remains poorly defined. METHODS Rifampicin activity alone and in combination with vancomycin against biofilm-forming MRSA was investigated, using a twofold serial… CONTINUE READING