Rif1 regulates telomere length through conserved HEAT repeats

  title={Rif1 regulates telomere length through conserved HEAT repeats},
  author={Calla B. Shubin and Rini Mayangsari and Ariel D. Swett and Carol W. Greider},
  journal={Nucleic Acids Research},
  pages={3967 - 3980}
Abstract In budding yeast, Rif1 negatively regulates telomere length, but the mechanism of this regulation has remained elusive. Previous work identified several functional domains of Rif1, but none of these has been shown to mediate telomere length. To define Rif1 domains responsible for telomere regulation, we localized truncations of Rif1 to a single specific telomere and measured telomere length of that telomere compared to bulk telomeres. We found that a domain in the N-terminus containing… 

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