Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching.


DNA double-strand breaks (DSBs) represent a threat to the genome because they can lead to the loss of genetic information and chromosome rearrangements. The DNA repair protein p53 binding protein 1 (53BP1) protects the genome by limiting nucleolytic processing of DSBs by a mechanism that requires its phosphorylation, but whether 53BP1 does so directly is… (More)
DOI: 10.1126/science.1230624


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