Rif1 Is Required for Resolution of Ultrafine DNA Bridges in Anaphase to Ensure Genomic Stability.

@article{Hengeveld2015Rif1IR,
  title={Rif1 Is Required for Resolution of Ultrafine DNA Bridges in Anaphase to Ensure Genomic Stability.},
  author={Rutger C. C. Hengeveld and H. Rudolf de Boer and Pepijn M. Schoonen and Elisabeth G. E. de Vries and Susanne M A Lens and Marcel A T M van Vugt},
  journal={Developmental cell},
  year={2015},
  volume={34 4},
  pages={466-74}
}
Sister-chromatid disjunction in anaphase requires the resolution of DNA catenanes by topoisomerase II together with Plk1-interacting checkpoint helicase (PICH) and Bloom's helicase (BLM). We here identify Rif1 as a factor involved in the resolution of DNA catenanes that are visible as ultrafine DNA bridges (UFBs) in anaphase to which PICH and BLM localize. Rif1, which during interphase functions downstream of 53BP1 in DNA repair, is recruited to UFBs in a PICH-dependent fashion, but… CONTINUE READING
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