Ridaifen-SB8, a novel tamoxifen derivative, induces apoptosis via reactive oxygen species-dependent signaling pathway.

@article{Guo2013RidaifenSB8AN,
  title={Ridaifen-SB8, a novel tamoxifen derivative, induces apoptosis via reactive oxygen species-dependent signaling pathway.},
  author={Wen-zhi Guo and Isamu Shiina and Yanwen Wang and Eri Umeda and Chihiro Watanabe and Shoko Uetake and Yoshimi Ohashi and Takao Yamori and Shingo Dan},
  journal={Biochemical pharmacology},
  year={2013},
  volume={86 9},
  pages={1272-84}
}
Tamoxifen is an anticancer agent widely used for treatment of estrogen receptor (ERα)-positive breast cancer. We previously developed a novel synthesis of tamoxifen and its derivatives, named Ridaifens (RIDs). Some of them, including RID-SB8, exhibited a stronger anticancer activity than tamoxifen in ERα-positive MCF-7 cells while having lost the affinity for ERα, suggesting an ERα-independent anticancer mode of action. In this study, we investigated the underlying mechanism by which RID-SB8… CONTINUE READING
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