Rictor is a novel target of p70 S6 kinase-1

  title={Rictor is a novel target of p70 S6 kinase-1},
  author={Caroline Treins and Patricia H. Warne and Mark A Magnuson and Mario Pende and Julian Downward},
The rapamycin-insensitive companion of mammalian target of rapamycin (mTOR) (Rictor) is a key member of mTOR complex-2 (mTORC2), which phosphorylates the AGC kinases Akt/PKB, PKC and SGK1 at a C-terminal hydrophobic motif. We identified several novel sites on Rictor that are phosphorylated, including Thr1135, which is conserved across all vertebrates. Phosphorylation of this site on Rictor is stimulated by amino acids and growth factors through a rapamycin-sensitive signaling cascade. We… CONTINUE READING


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