Rickettsial outer-membrane protein B (rOmpB) mediates bacterial invasion through Ku70 in an actin, c-Cbl, clathrin and caveolin 2-dependent manner.

@article{Chan2009RickettsialOP,
  title={Rickettsial outer-membrane protein B (rOmpB) mediates bacterial invasion through Ku70 in an actin, c-Cbl, clathrin and caveolin 2-dependent manner.},
  author={Yvonne Gar-Yun Chan and Marissa M. Cardwell and Timothy M Hermanas and Tsuneo Uchiyama and Juan Jos{\'e} Martinez},
  journal={Cellular microbiology},
  year={2009},
  volume={11 4},
  pages={629-44}
}
Rickettsia conorii, an obligate intracellular tick-borne pathogen and the causative agent of Mediterranean spotted fever, binds to and invades non-phagocytic mammalian cells. Previous work identified Ku70 as a mammalian receptor involved in the invasion process and identified the rickettsial autotransporter protein, rOmpB, as a ligand; however, little is known about the role of Ku70-rOmpB interactions in the bacterial invasion process. Using an Escherichia coli heterologous expression system… CONTINUE READING
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