Rickettsial metK-encoded methionine adenosyltransferase expression in an Escherichia coli metK deletion strain.

@article{Driskell2005RickettsialMM,
  title={Rickettsial metK-encoded methionine adenosyltransferase expression in an Escherichia coli metK deletion strain.},
  author={Lonnie O. Driskell and Aimee Marie Tucker and Herbert H. Winkler and David O. Wood},
  journal={Journal of bacteriology},
  year={2005},
  volume={187 16},
  pages={
          5719-22
        }
}
The obligate intracellular bacterium Rickettsia prowazekii has recently been shown to transport the essential metabolite S-adenosylmethionine (SAM). The existence of such a transporter would suggest that the metK gene, coding for the enzyme that synthesizes SAM, is unnecessary for rickettsial growth. Genome sequencing has revealed that this is the case for the metK genes of the spotted fever group and the Madrid E strain of R. prowazekii, which contain recognizable inactivating mutations… CONTINUE READING

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