Rickettsia, typhus and the mitochondrial connection

  title={Rickettsia, typhus and the mitochondrial connection},
  author={Michael W. Gray},
  • M. W. Gray
  • Published 12 November 1998
  • Biology, Medicine
  • Nature
The genome sequence ofRickettsia prowazekii, the agent that causes typhus, has been determined. What emerges is a snapshot of genome re-tailoring in a parasitic bacterium, and a new look at the evolutionary connection between Rickettsiaand mitochondria. 
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  • Biology
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • 2016
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The genome of Rickettsia prowazekii and some thoughts on the origin of mitochondria and hydrogenosomes.
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  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 1999
Rickettsia's genome encodes an ATP-generating machinery that is strikingly similar to that of aerobic mitochondria, but it does not encode homologues for the ATP-producing pathways of anaerobic mitochondria or hydrogenosomes, leaving an important issue regarding the origin and nature of the ancestral mitochondrial symbiont unresolved.
The origin and early evolution of mitochondria
Complete sequences of numerous mitochondrial, many prokaryotic, and several nuclear genomes are now available and confirm that the mitochondrial genome originated from a eubacterial ancestor but raise questions about the evolutionary antecedents of the mitochondrial proteome.
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The enormous amount of data generated by the various genome-sequencing projects has led to a plethora of studies addressing the evolutionary history of life on Earth.
A Rickettsiales symbiont of amoebae with ancient features.
The deeply branching phylogenetic position of 'Candidatus Jidaibacter acanthamoeba' together with its ancient features place it closely to the rickettsial ancestor and helps to better understand the transition from a free-living to an intracellular lifestyle.
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Development of Rickettsia prowazekii DNA Vaccine
Rickettsia prowazekii target genes have been PCR amplified and a group of genes involved in invasion, cell division, protein secretion, and virulence, and fifteen have been introduced into the pENTR/SD/D‐TOPO entry cloning vector.
Endosymbiosis in Ecology and Evolution
Endosymbionts and the Origin of Emerging Pathogens, Symbioses and Evolution, and Symbiotrophic Systems: Definition and Examples.


The genome sequence of Rickettsia prowazekii and the origin of mitochondria
The complete genome sequence of the obligate intracellular parasite Rickettsia prowazekii, the causative agent of epidemic typhus, is described, which contains 834 protein-coding genes and is more closely related to mitochondria than is any other microbe studied so far.
An ancestral mitochondrial DNA resembling a eubacterial genome in miniature
Feature of gene content together with eubacterial characteristics of genome organization and expression not found before in mitochondrial genomes indicate that R. americana mtDNA more closely resembles the ancestral proto-mitochondrial genome than any other mtDNA investigated to date.