Rickettsia, typhus and the mitochondrial connection

@article{Gray1998RickettsiaTA,
  title={Rickettsia, typhus and the mitochondrial connection},
  author={Michael W. Gray},
  journal={Nature},
  year={1998},
  volume={396},
  pages={109-110}
}
  • M. W. Gray
  • Published 12 November 1998
  • Biology, Medicine
  • Nature
The genome sequence ofRickettsia prowazekii, the agent that causes typhus, has been determined. What emerges is a snapshot of genome re-tailoring in a parasitic bacterium, and a new look at the evolutionary connection between Rickettsiaand mitochondria. 
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References

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The genome sequence of Rickettsia prowazekii and the origin of mitochondria
TLDR
The complete genome sequence of the obligate intracellular parasite Rickettsia prowazekii, the causative agent of epidemic typhus, is described, which contains 834 protein-coding genes and is more closely related to mitochondria than is any other microbe studied so far.
An ancestral mitochondrial DNA resembling a eubacterial genome in miniature
TLDR
Feature of gene content together with eubacterial characteristics of genome organization and expression not found before in mitochondrial genomes indicate that R. americana mtDNA more closely resembles the ancestral proto-mitochondrial genome than any other mtDNA investigated to date.
RATS, LICE AND HISTORY
TLDR
This book is devoted to a discussion of the biology of Typhus and history of typhus fever in human affairs, which combines Zinsser's expertise in biology with his broad knowledge of the humanities.