Rickets in the Middle East: role of environment and genetic predisposition.

@article{Baroncelli2008RicketsIT,
  title={Rickets in the Middle East: role of environment and genetic predisposition.},
  author={Giampiero I. Baroncelli and Abdullah Bereket and Mohamed El Kholy and Laura Aud{\'i} and Yaşar Cesur and Behzat Ozkan and Mona Mohamed Rashad and M{\'o}nica Fern{\'a}ndez-Cancio and Yoseph Weisman and Giuseppe Saggese and Ze’ev Hochberg},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2008},
  volume={93 5},
  pages={
          1743-50
        }
}
CONTEXT The Middle East has a high incidence of rickets, and it is also common in Europe-dwelling children of Middle Eastern origin. OBJECTIVE The objective of the study was to explore the mechanisms leading to rickets in children of the Middle East. DESIGN AND SETTING We conducted a prospective study in 98 rachitic and 50 controls (aged 6 months to 4 yr) from university and community outpatient hospitals in Egypt and Turkey. MAIN OUTCOME MEASURES We collected epidemiological, maternal… 
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125 Citations
Highly Influential Citations
8
Background Citations
51
Methods Citations
2
Results Citations
5

125 Citations

Citation Type

Citation Type

Prevalence of vitamin D deficiency rickets in the eastern part of Turkey
TLDR
It was concluded that, although VDDR has been a continuing childhood health problem, a nationwide free vitamin D supplementation campaign initiated by the government appeared to be effective in eliminating VD DR.
Hypovitaminosis D in the Middle East and North Africa
TLDR
The lack of populations based studies, gaps in studies in infants, pre-pubertal children and pregnant women, hinder the development of region specific guidelines and constitute a major obstacle to impact this chronic and most often subclinical disease.
Risk Factor for Nutritional Rickets among 0-5 Years Children in Bangladesh
TLDR
Exclusive breastfeeding for >4 months, sunlight exposure <30 minutes/day, dark skin color, number of siblings, urban slum residence, deficit monthly income, and parent’s education are the risk factors for NR in Bangladeshi child.
Nutritional Rickets among Children in a Sun Rich Country
TLDR
The most important risk factors were low vitamin D and calcium intakes, lack of exposure to sunlight, prolonged breast feeding without supplementation of vitamin D, and diabetes mellitus.
Rickets and Its Associated Factors among Under-Five Children in Selected Public Hospitals in Eastern Ethiopia
TLDR
Being under the care of caregivers, dressing fully and no oil massage during sun exposure, and being sick one month prior to the study were significantly associated with rickets.
Vitamin D Deficiency in the Middle East and its Health Consequences for Children and Adults
TLDR
Suggestions for vitamin D replacement doses based on evidence available to-date are provided, as Hypovitaminosis D is a major public health problem across all life stages in the Middle East with deleterious immediate and latent manifestations and long term strategies should include public education, national health policies for screening and prevention through food fortification, and treatment through vitamin D supplementation.
Incidence and Risk Factors of Rachitic Genu Varus in Preschool Children in a Paediatric Health Institute in Egypt as One of the Developing Countries
TLDR
Vitamin D deficiency rachitic genu varus is a multifactorial condition in Egypt, and raising the standard of living, level of education, housings, and dietary supplementation of vitamin D to the pregnant women and infants are the solution.
Nutritional rickets: vitamin D, calcium, and the genetic make-up
TLDR
Although patients presented epidemiologic factors strongly contributing to rickets, genetic modulation affecting predisposition, severity, and clinical course is exerted, at least in part, by VDR gene polymorphic variation.
Nutritional rickets around the world
  • A. Prentice
  • Medicine
    The Journal of Steroid Biochemistry and Molecular Biology
  • 2013
Prevalence and Clinical Characteristics of Rickets in Infants and Children Attending the Outpatient Clinic at Damietta University Hospital
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