Rickets in Nigerian children: a consequence of calcium malnutrition.

  title={Rickets in Nigerian children: a consequence of calcium malnutrition.},
  author={Friday Okonofua and Devinder S Gill and Z. O. Alabi and Muriel Thomas and J. L. Bell and Paresh Dandona},
  journal={Metabolism: clinical and experimental},
  volume={40 2},
Eleven Nigerian children with clinically and radiologically proven rickets were assessed biochemically. The children had low or low normal concentrations of total and corrected calcium, and elevated plasma alkaline phosphatase (ALP) activity, but normal plasma phosphate concentrations. Their serum 25-hydroxyvitamin D (25-OHD) and 1,25-dihydroxyvitamin D (1,25-(OH)2D) concentrations were not significantly different from those in controls, but the ratio of 1,25-(OH)2D to 25-OHD was significantly… CONTINUE READING