Ricin Toxicokinetics and Its Sensitive Detection in Mouse Sera or Feces Using Immuno-PCR

@inproceedings{He2010RicinTA,
  title={Ricin Toxicokinetics and Its Sensitive Detection in Mouse Sera or Feces Using Immuno-PCR},
  author={Xiaohua He and Stephanie A. McMahon and Thomas D. Henderson and Stephen M. Griffey and Luisa W Cheng},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Ricin (also called RCA-II or RCA(60)), one of the most potent toxins and documented bioweapons, is derived from castor beans of Ricinus communis. Several in vitro methods have been designed for ricin detection in complex food matrices in the event of intentional contamination. Recently, a novel Immuno-PCR (IPCR) assay was developed with a limit of detection of 10 fg/ml in a buffer matrix and about 10-1000-fold greater sensitivity than other methods in various food matrices. METHODS… CONTINUE READING