Richter's syndrome with identification of marker chromosomes.

  title={Richter's syndrome with identification of marker chromosomes.},
  author={Peter H. Fitzgerald and Christine M. McEwan and J. W. Hamer and Michael E. J. Beard},
  volume={46 1},
A case is presented of a man with Richter's syndrome with diffuse histiocytic lymphoma following a ten-year history of untreated chronic lymphatic leukemia. He did not respond to therapy. The lymphoma cells had 61 chromosomes with aneuploidy of 13 chromosomes and 11 structurally altered chromosomes. Only chromosomes 8, 9, 12, 14, and 18 were diploid and without abnormality. Significantly, part of chromsome 1q was duplicated as in the partial trisomy of 1q reported to characterize a number of… CONTINUE READING