Richner-Hanhart's syndrome: new ultrastructural observations on skin lesions of two cases.

@article{ElShoura1997RichnerHanhartsSN,
  title={Richner-Hanhart's syndrome: new ultrastructural observations on skin lesions of two cases.},
  author={S. M. El-Shoura and Talal M Tallab},
  journal={Ultrastructural pathology},
  year={1997},
  volume={21 1},
  pages={51-6}
}
New ultrastructural observations are described in skin lesions of two brothers with Richner-Hanhart's syndrome (RHS). Physical examination of the two patients showed painful skin lesions of palms and soles combined with denderitic corneal ulceration and mental retardation. The diagnosis of RHS was confirmed biochemically with high tyrosine levels in both blood and urine. Examination by transmission electron microscopy revealed several abnormal ultrastructural changes in the epidermal cells. The… CONTINUE READING