Richard Darwin Keynes CBE. 14 August 1919 — 12 June 2010

  title={Richard Darwin Keynes CBE. 14 August 1919 — 12 June 2010},
  author={IAN M. Glynn},
  journal={Biographical Memoirs of Fellows of the Royal Society},
  pages={205 - 227}
  • I. Glynn
  • Published 1 December 2011
  • Biology
  • Biographical Memoirs of Fellows of the Royal Society
From the time that Richard Keynes became a research student in 1946, until well after he retired in 1986, a main aim of his work was to get a better understanding of the machinery in nerve cells that was responsible for the changes in the fluxes of sodium and potassium ions that Alan Hodgkin and Andrew Huxley had shown give rise to ‘action potentials’—the transient ‘all-or-nothing’ alterations in transmembrane voltage that are the sole constituent of messages transmitted along nerve fibres. In… 

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Kinetic analysis of the sodium gating current in the squid giant axon
A critical study has been made of the characteristics of the kinetic components of the sodium gating current in the squid giant axon, of which not less than five can be resolved. In addition to the
Properties of the voltage sensor for the opening and closing of the sodium channels in the squid giant axon
  • R. Keynes, H. Meves
  • Biology
    Proceedings of the Royal Society of London. Series B: Biological Sciences
  • 1993
The results provide further support for the proposal of Keynes (1992) that the S4 voltage-sensing units of the homology domains are responsible only for the transitions between the several resting, activated and inactivated states of the channel in which it remains closed, and a separate C⇌O voltage sensor controls the transitions to and from the two open states.
The mobility and diffusion coefficient of potassium in giant axons from Sepia
It is suggested that at least 90% of the total potassium is free to exchange with radioactive potassium, and therefore the results of the present study apply to the bulk of the potassium inside the axoplasm.
Activation, inactivation and recovery in the sodium channels of the squid giant axon dialysed with different solutions.
Comparisons were made between families of ion currents recorded in voltage-clamped squid axons dialysed with 20 mM NaF and 330 mM CsF or TMAF, and bathed in a solution in which four fifths of the Na
Kinetics and steady‐state properties of the charged system controlling sodium conductance in the squid giant axon
1. Asymmetries in the early time course of the displacement current passing across the membrane after application of equal voltage‐clamp pulses in the two directions have been investigated in the
Changes in light scattering that accompany the action potential in squid giant axons: potential‐dependent components
1. To obtain information about structural events that occur in axons, changes in light scattering from squid giant axons were measured during action potentials and voltage‐clamp steps.
Changes in light scattering associated with the action potential in crab nerves
1. Changes in light scattering from stimulated crab leg nerves were measured in an effort to study changes in structure that occur during the action potential.
hodgkin) The mobility of potassium in the axis cylinder of a giant
  • Arch. Sci. Physiol
  • 1950