Richard Darwin Keynes CBE. 14 August 1919 — 12 June 2010

@article{Glynn2011RichardDK,
  title={Richard Darwin Keynes CBE. 14 August 1919 — 12 June 2010},
  author={IAN M. Glynn},
  journal={Biographical Memoirs of Fellows of the Royal Society},
  year={2011},
  pages={205 - 227}
}
  • I. Glynn
  • Published 1 December 2011
  • Biology
  • Biographical Memoirs of Fellows of the Royal Society
From the time that Richard Keynes became a research student in 1946, until well after he retired in 1986, a main aim of his work was to get a better understanding of the machinery in nerve cells that was responsible for the changes in the fluxes of sodium and potassium ions that Alan Hodgkin and Andrew Huxley had shown give rise to ‘action potentials’—the transient ‘all-or-nothing’ alterations in transmembrane voltage that are the sole constituent of messages transmitted along nerve fibres. In… 

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References

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TLDR
The results provide further support for the proposal of Keynes (1992) that the S4 voltage-sensing units of the homology domains are responsible only for the transitions between the several resting, activated and inactivated states of the channel in which it remains closed, and a separate C⇌O voltage sensor controls the transitions to and from the two open states.
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It is suggested that at least 90% of the total potassium is free to exchange with radioactive potassium, and therefore the results of the present study apply to the bulk of the potassium inside the axoplasm.
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