Rich club analysis in the Alzheimer's disease connectome reveals a relatively undisturbed structural core network.

@article{Daianu2015RichCA,
  title={Rich club analysis in the Alzheimer's disease connectome reveals a relatively undisturbed structural core network.},
  author={Madelaine Daianu and Neda Jahanshad and Talia M. Nir and Clifford R. Jack and Michael W Weiner and Matt A. Bernstein and Paul M. Thompson},
  journal={Human brain mapping},
  year={2015},
  volume={36 8},
  pages={
          3087-103
        }
}
Diffusion imaging can assess the white matter connections within the brain, revealing how neural pathways break down in Alzheimer's disease (AD). We analyzed 3-Tesla whole-brain diffusion-weighted images from 202 participants scanned by the Alzheimer's Disease Neuroimaging Initiative-50 healthy controls, 110 with mild cognitive impairment (MCI) and 42 AD patients. From whole-brain tractography, we reconstructed structural brain connectivity networks to map connections between cortical regions… CONTINUE READING
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