Ribozymes, riboswitches and beyond: regulation of gene expression without proteins

@article{Serganov2007RibozymesRA,
  title={Ribozymes, riboswitches and beyond: regulation of gene expression without proteins},
  author={Alexander Serganov and Dinshaw J. Patel},
  journal={Nature Reviews Genetics},
  year={2007},
  volume={8},
  pages={776-790}
}
Although various functions of RNA are carried out in conjunction with proteins, some catalytic RNAs, or ribozymes, which contribute to a range of cellular processes, require little or no assistance from proteins. Furthermore, the discovery of metabolite-sensing riboswitches and other types of RNA sensors has revealed RNA-based mechanisms that cells use to regulate gene expression in response to internal and external changes. Structural studies have shown how these RNAs can carry out a range of… CONTINUE READING
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