Ribozyme Catalysis of Metabolism in the RNA World

@article{Chen2007RibozymeCO,
  title={Ribozyme Catalysis of Metabolism in the RNA World},
  author={Xi Chen and Na Li and Andrew D. Ellington},
  journal={Chemistry \& Biodiversity},
  year={2007},
  volume={4}
}
In vitro selection has proven to be a useful means of explore the molecules and catalysts that may have existed in a primoridal ‘RNA world’. By selecting binding species (aptamers) and catalysts (ribozymes) from random sequence pools, the relationship between biopolymer complexity and function can be better understood, and potential evolutionary transitions between functional molecules can be charted. In this review, we have focused on several critical events or transitions in the putative RNA… 

Topics from this paper

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Results suggest that the existing polymerase ribozyme is not well suited to using an arginine cofactor, because this is the amino acid most adept to interact with RNA.
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TLDR
This Perspective summarizes the known types of ligand-controlled ribozymes and riboswitches and discusses the reasons why allosteric riboz enzymes formed by fusion of RNA enzymes and RNA aptamers are rare in today’s biological systems.
Evolutionary origins and directed evolution of RNA.
TLDR
In vitro selection experiments show first and foremost that it is possible that functional nucleic acids can arise from random sequence libraries, and can give a true and quantitative idea of the likelihood that these scenarios could have played out in the RNA world.
Model systems for primordial enzymes
Primordial life forms are believed to have used versatile RNA molecules to catalyze reactions and mediate their own replication. With increasing complexity of these systems, Nature explored
Studies towards the prebiotic synthesis and phosphorylation of ribonucleotides
TLDR
The discovery of a generational node in the network of prebiotic chemistry that links the syntheses of amino acids with nucleotides 5'-phosphates suggests that these different groups of metabolites need not have arisen from separate chemistries, helping to get a better understanding of the processes governing the chemical evolution of life.
Lower temperature optimum of a smaller, fragmented triphosphorylation ribozyme.
TLDR
A 96-nucleotide long ribozyme is developed, which generates a chemically activated 5'-phosphate (a 5'-triph phosphate) from a prebiotically plausible molecule, trimetaphosphate, and an RNA 5'-hydroxyl group by fragmenting the ribo enzyme into multiple RNA strands, and by successively removing its longest double strand.
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