Ribotoxic stress through p38 mitogen-activated protein kinase activates in vitro the human pyrin inflammasome.

@article{Yu2013RibotoxicST,
  title={Ribotoxic stress through p38 mitogen-activated protein kinase activates in vitro the human pyrin inflammasome.},
  author={Je-Wook Yu and Andrew Farias and Inhwa Hwang and Teresa Fernandes-Alnemri and Emad S. Alnemri},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 16},
  pages={11378-83}
}
Human pyrin with gain-of-function mutations in its B30.2/SPRY domain causes the autoinflammatory disease familial Mediterranean fever by assembling an ASC-dependent inflammasome that activates caspase-1. Wild-type human pyrin can also form an inflammasome complex with ASC after engagement by autoinflammatory PSTPIP1 mutants. How the pyrin inflammasome is activated in the absence of disease-associated mutations is not yet known. We report here that ribotoxic stress triggers the assembly of the… CONTINUE READING