Riboswitches that sense S-adenosylhomocysteine and activate genes involved in coenzyme recycling.

@article{Wang2008RiboswitchesTS,
  title={Riboswitches that sense S-adenosylhomocysteine and activate genes involved in coenzyme recycling.},
  author={Joy Xin Wang and Elaine R. Lee and Dianali Rivera Morales and Jinsoo Lim and Ronald R. Breaker},
  journal={Molecular cell},
  year={2008},
  volume={29 6},
  pages={691-702}
}
We have identified a highly conserved RNA motif that occurs upstream of genes involved in S-adenosyl-L-methionine (SAM) recycling in many Gram-positive and Gram-negative species of bacteria. The phylogenetic distribution and the conserved structural features of representatives of this motif are indicative of riboswitch function. Riboswitches are widespread metabolite-sensing gene control elements that are typically found in the 5' untranslated regions (UTRs) of bacterial mRNAs. We… CONTINUE READING
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