Ribosome-targeting antibiotics and mechanisms of bacterial resistance

@article{Wilson2013RibosometargetingAA,
  title={Ribosome-targeting antibiotics and mechanisms of bacterial resistance},
  author={Daniel N. Wilson},
  journal={Nature Reviews Microbiology},
  year={2013},
  volume={12},
  pages={35-48}
}
The ribosome is one of the main antibiotic targets in the bacterial cell. Crystal structures of naturally produced antibiotics and their semi-synthetic derivatives bound to ribosomal particles have provided unparalleled insight into their mechanisms of action, and they are also facilitating the design of more effective antibiotics for targeting multidrug-resistant bacteria. In this Review, I discuss the recent structural insights into the mechanism of action of ribosome-targeting antibiotics… Expand

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