Ribosome-targeting antibiotics and mechanisms of bacterial resistance

  title={Ribosome-targeting antibiotics and mechanisms of bacterial resistance},
  author={D. Wilson},
  journal={Nature Reviews Microbiology},
  • D. Wilson
  • Published 2013
  • Biology, Medicine
  • Nature Reviews Microbiology
  • The ribosome is one of the main antibiotic targets in the bacterial cell. Crystal structures of naturally produced antibiotics and their semi-synthetic derivatives bound to ribosomal particles have provided unparalleled insight into their mechanisms of action, and they are also facilitating the design of more effective antibiotics for targeting multidrug-resistant bacteria. In this Review, I discuss the recent structural insights into the mechanism of action of ribosome-targeting antibiotics… CONTINUE READING
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