Ribosome stalling regulates IRES-mediated translation in eukaryotes, a parallel to prokaryotic attenuation.

@article{Fernandez2005RibosomeSR,
  title={Ribosome stalling regulates IRES-mediated translation in eukaryotes, a parallel to prokaryotic attenuation.},
  author={James M. Fernandez and Ibrahim Abu Yaman and Charles T. L. Huang and Hongmei Liu and Alex B Lopez and Anton A. Komar and Mark G. Caprara and William C. Merrick and Martin D. Snider and Randal J Kaufman and Wouter H. Lamers and Maria Hatzoglou},
  journal={Molecular cell},
  year={2005},
  volume={17 3},
  pages={405-16}
}
It was previously shown that the mRNA for the cat-1 Arg/Lys transporter is translated from an internal ribosome entry site (IRES) that is regulated by cellular stress. Amino acid starvation stimulated cat-1 translation via a mechanism that requires translation of an ORF in the mRNA leader and remodeling of the leader to form an active IRES (the "zipper model" of translational control). It is shown here that slowing of the leader peptide elongation rate, either by cycloheximide or the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

Similar Papers

Loading similar papers…