Ribosome profiling reveals pervasive translation outside of annotated protein-coding genes.

@article{Ingolia2014RibosomePR,
  title={Ribosome profiling reveals pervasive translation outside of annotated protein-coding genes.},
  author={Nicholas T Ingolia and Gloria Ann Brar and Noam Stern-Ginossar and Michael S. Harris and Ga{\"e}lle J. S. Talhouarne and Sarah E Jackson and Mark R Wills and Jonathan S. Weissman},
  journal={Cell reports},
  year={2014},
  volume={8 5},
  pages={1365-79}
}
Ribosome profiling suggests that ribosomes occupy many regions of the transcriptome thought to be noncoding, including 5' UTRs and long noncoding RNAs (lncRNAs). Apparent ribosome footprints outside of protein-coding regions raise the possibility of artifacts unrelated to translation, particularly when they occupy multiple, overlapping open reading frames (ORFs). Here, we show hallmarks of translation in these footprints: copurification with the large ribosomal subunit, response to drugs… CONTINUE READING
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