Ribosome-inactivating proteins depurinate poly(ADP-ribosyl)ated poly(ADP-ribose) polymerase and have transforming activity for 3T3 fibroblasts.

@article{Barbieri2003RibosomeinactivatingPD,
  title={Ribosome-inactivating proteins depurinate poly(ADP-ribosyl)ated poly(ADP-ribose) polymerase and have transforming activity for 3T3 fibroblasts.},
  author={Luigi Barbieri and Maurizio Brigotti and Paolo Perocco and Domenica Carnicelli and Marialibera Ciani and Laura Mercatali and Fiorenzo Stirpe},
  journal={FEBS letters},
  year={2003},
  volume={538 1-3},
  pages={178-82}
}
It has been known that ribosome-inactivating proteins (RIPs) from plants damage ribosomes by removing adenine from a precise position of rRNA. Subsequently it was observed that all tested RIPs depurinate DNA, and some of them also non-ribosomal RNAs and poly(A), hence the denomination of adenine polynucleotide glycosylases was proposed. We report now that… CONTINUE READING