Ribosome flow model with extended objects.

  title={Ribosome flow model with extended objects.},
  author={Yoram Zarai and Michael Margaliot and Tamir Tuller},
  journal={Journal of the Royal Society, Interface},
  volume={14 135}
We study a deterministic mechanistic model for the flow of ribosomes along the mRNA molecule, called the ribosome flow model with extended objects (RFMEO). This model encapsulates many realistic features of translation including non-homogeneous transition rates along mRNA, the fact that every ribosome covers several codons, and the fact that ribosomes cannot overtake one another. The RFMEO is a mean-field approximation of an important model from statistical mechanics called the totally… CONTINUE READING