Ribosome fidelity: tRNA discrimination, proofreading and induced fit.

  title={Ribosome fidelity: tRNA discrimination, proofreading and induced fit.},
  author={Marina V. Rodnina and Wolfgang Wintermeyer},
  journal={Trends in biochemical sciences},
  volume={26 2},
The ribosome selects aminoacyl-tRNAs with high fidelity. Kinetic studies reveal that codon-anticodon recognition both stabilizes aminoacyl-tRNA binding on the ribosome and accelerates reactions of the productive pathway, indicating an important contribution of induced fit to substrate selection. Similar mechanisms are used by other template-programmed enzymes, such as DNA and RNA polymerases. 

From This Paper

Figures, tables, and topics from this paper.
39 Citations
35 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 39 extracted citations


Publications referenced by this paper.
Showing 1-10 of 35 references

Conformational switch in the decoding region of 16 S rRNAduring aminoacyltRNAselection on the ribosome

  • J. S. Lodmell, A. E. Dahlberg
  • Nat . Struct . Biol .
  • 2000

Solution structure of the E . coli 70 S ribosome at 11 . 5 Å resolution

  • M. O’Connor, A. E. Dahlberg
  • 2000

Structure of the 30 S ribosomal subunit

  • F. Schluenzen
  • Nature
  • 2000

Zink ion mediated amino acid discrimination by threonyltRNAsynthetases

  • R. Sankaranarayanan
  • Nat . Struct . Biol .
  • 2000

Insights into editing from an IletRNAsynthetase structure with tRNAIleand mupirocin

  • L. F. Silvian
  • Science
  • 1999

Recognition of the codon – anticodon helix by ribosomal RNA

  • D. I. Van Ryk, A. E. Dahlberg
  • Science
  • 1999

Similar Papers

Loading similar papers…