Ribosome biogenesis is a downstream effector of the oncogenic U2AF1-S34F mutation

@article{Akef2019RibosomeBI,
  title={Ribosome biogenesis is a downstream effector of the oncogenic U2AF1-S34F mutation},
  author={Abdalla Akef and K. McGraw and S. Cappell and D. Larson},
  journal={bioRxiv},
  year={2019}
}
U2AF1 forms a heterodimeric complex with U2AF2 that is primarily responsible for 3’ splice site selection. U2AF1 mutations have been identified in most cancers but are prevalent in Myelodysplastic Syndrome and Acute Myeloid Leukemia, and the most common mutation is a missense substitution of serine-34 to phenylalanine (S34F). However, the U2AF heterodimer also has a non-canonical function as a translational regulator. Here, we report that the U2AF1 S34F mutation results in specific mis… Expand
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