Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl transferase responsible for 18S rRNA hypermodification in yeast and humans

@inproceedings{Meyer2016RibosomeBF,
  title={Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl transferase responsible for 18S rRNA hypermodification in yeast and humans},
  author={Britta Meyer and Jan Philip Wurm and Sunny Sharma and Carina Immer and Denys Pogoryelov and Peter K{\"o}tter and Denis L J Lafontaine and Jens W{\"o}hnert and Karl-Dieter Entian},
  booktitle={Nucleic acids research},
  year={2016}
}
The chemically most complex modification in eukaryotic rRNA is the conserved hypermodified nucleotide N1-methyl-N3-aminocarboxypropyl-pseudouridine (m(1)acp(3)Ψ) located next to the P-site tRNA on the small subunit 18S rRNA. While S-adenosylmethionine was identified as the source of the aminocarboxypropyl (acp) group more than 40 years ago the enzyme catalyzing the acp transfer remained elusive. Here we identify the cytoplasmic ribosome biogenesis protein Tsr3 as the responsible enzyme in yeast… CONTINUE READING
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